Public health and health service interventions are typically complex: they are multifaceted,
with impacts at multiple levels and on multiple stakeholders. Systematic reviews evaluating …

Bisphosphonates (BPs) are well established as the leading drugs for the treatment of
osteoporosis. There is new knowledge about how they work. The differences that exist …

Background Bone is the most common site of metastatic disease associated with breast
cancer (BC). Bisphosphonates inhibit osteoclast‐mediated bone resorption, and novel …

Bisphosphonates (BPs) are highly effective in treating osteoporosis and reducing hip,
vertebral, and other fractures by as much as 50% to 70%. However, since 2006, atypical …

The number of patients with bone metastasis increases as medical management and
surgery improve the overall survival of patients with cancer. Bone metastasis can cause …

Background: Evidence-based clinical guidelines aim to improve the quality of care. In The
Netherlands, considerable time and effort have been invested in the development and …

Tumour-associated macrophages, TAMs, play a pivotal role in tumour growth and
metastasis by promoting tumour angiogenesis. Treatment with clodronate encapsulated in …

The purpose of this article is to provide an overview of the latest applications of
organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs …

Objective: To compile and critique research on the diagnostic accuracy of individual
orthopaedic physical examination tests in a manner that would allow clinicians to judge …

The profound effects of the bisphosphonates on calcium metabolism were discovered over
30 years ago, and they are now well established as the major drugs used for the treatment of …