Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …

High-voltage-activated R-type CaV2. 3 channel plays pivotal roles in many physiological
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …

Dystonia is a clinically, genetically, and biologically heterogeneous hyperkinetic movement
disorder caused by the dysfunctional activity of neural circuits involved in motor control. Our …

Voltage-gated Ca2+ channels translate the electrical inputs of excitable cells into
biochemical outputs by controlling influx of the ubiquitous second messenger Ca2+. As such …

Serotonin (5-HT) is an important neurotransmitter in the central nervous system where it
modulates circuits involved in mood, cognition, movement, arousal, and autonomic function …

Over the last years, a constantly increasing number of genetic diseases associated with
epilepsy and movement disorders have been recognized. An emerging group of conditions …

G i/o-coupled G protein-coupled receptors can inhibit neurotransmitter release at synapses
via multiple mechanisms. In addition to Gβγ-mediated modulation of voltage-gated calcium …

In animal cells, Gα subunit of the heterotrimeric G proteins can bind to both the N-terminal
and C-terminal domains of G-protein-activated inwardly rectifying K+ channels (GIRKs) to …

High voltage-activated calcium channels (HVACCs) are essential for synaptic and
nociceptive transmission. Although blocking HVACCs can effectively reduce pain, this …