Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper
presents the oxygen demand of different cells and summarizes experimental and numerical …

With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …

The performance of an agitated bioreactor is hampered by an intense shear environment
and low mass-transfer coefficient (k L a). The gas hold-up, k L a, and shear environment …

The use of coaxial mixers has significantly improved gas dispersion in non-Newtonian fluids.
However, to the best of our knowledge, no scale-up investigation of an aerated coaxial mixer …

Abstract Computational Fluid Dynamics (CFD) is a valuable tool for studying fluid
environments within cell culture bioreactors and optimizing processing parameters, but it …

Cultivated meat production was developed as a response to the rapidly increasing demand
for meat consumption. Bioreactor designs were adapted from other bioprocesses to account …

Cultured meat, an emerging technology in the alternative protein landscape, aims to provide
a sustainable and animal-friendly protein source to complement traditional meat production …

The evolution of the rheological behavior of the fluid is one of the primary challenges
encountered in the scale-up of the most aerated reactors. In fact, mixing efficiency …

In this work, a kinetics‐integrated CFD model based on coupling computational fluid
dynamics (CFD) and biokinetic was developed to guide the industrial scale‐up for …

So far, power input has been used as the main parameter for bioreactor scale‐up/‐down in
upstream process development and manufacturing. The rationale is that maintaining a …