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Genome mining for the search and discovery of bioactive compounds: the Streptomyces paradigm
AC Ward, NEE Allenby - FEMS microbiology letters, 2018 - academic.oup.com
The need for new antimicrobials is indisputable. The flight from natural products in drug
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …
Marine pharmacology in 2016–2017: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral …
AMS Mayer, AJ Guerrero, AD Rodríguez… - Marine drugs, 2021 - mdpi.com
The review of the 2016–2017 marine pharmacology literature was prepared in a manner
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …
Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly
associated with certain actinobacterial and proteobacterial lineages. These molecules have …
associated with certain actinobacterial and proteobacterial lineages. These molecules have …
The biological and chemical diversity of tetramic acid compounds from marine-derived microorganisms
M Jiang, S Chen, J Li, L Liu - Marine Drugs, 2020 - mdpi.com
Tetramic acid (pyrrolidine-2, 4-dione) compounds, isolated from a variety of marine and
terrestrial organisms, have attracted considerable attention for their diverse, challenging …
terrestrial organisms, have attracted considerable attention for their diverse, challenging …
Natural products as anthelmintics: safeguarding animal health
Covering literature to December 2022 This review provides a comprehensive account of all
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …
[HTML][HTML] Characterisation of the Antibiotic Profile of Lysobacter capsici AZ78, an Effective Biological Control Agent of Plant Pathogenic Microorganisms
F Brescia, A Vlassi, A Bejarano, B Seidl… - Microorganisms, 2021 - mdpi.com
Determining the mode of action of microbial biocontrol agents plays a key role in their
development and registration as commercial biopesticides. The biocontrol rhizobacterium …
development and registration as commercial biopesticides. The biocontrol rhizobacterium …
[HTML][HTML] Methods in microbial biodiscovery
This review presents an account of the microbial biodiscovery methodology developed and
applied in our laboratory at The University of Queensland, Institute for Molecular Bioscience …
applied in our laboratory at The University of Queensland, Institute for Molecular Bioscience …
Discovery and biosynthesis of pseudoamides reveal enzymatic cyclization of the polyene precursor to 5–5 bicyclic tetramate macrolactams
X Li, Q Liu, H Zou, J Luo, Y Jiao, H Wang, L Du… - ACS …, 2023 - ACS Publications
Polycyclic tetramate macrolactams (PoTeMs) comprise a family of pharmacologically
promising macrolactams that possess a tetramic acid moiety and various carbocyclic ring …
promising macrolactams that possess a tetramic acid moiety and various carbocyclic ring …
[HTML][HTML] The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and …
Venom is a known source of novel antimicrobial natural products. The substantial,
increasing number of these discoveries have unintentionally culminated in the …
increasing number of these discoveries have unintentionally culminated in the …
Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont
TY Nechitaylo, M Sandoval-Calderón, T Engl… - Proceedings of the …, 2021 - pnas.org
Genome erosion is a frequently observed result of relaxed selection in insect nutritional
symbionts, but it has rarely been studied in defensive mutualisms. Solitary beewolf wasps …
symbionts, but it has rarely been studied in defensive mutualisms. Solitary beewolf wasps …