Genome mining for the search and discovery of bioactive compounds: the Streptomyces paradigm

AC Ward, NEE Allenby - FEMS microbiology letters, 2018 - academic.oup.com
The need for new antimicrobials is indisputable. The flight from natural products in drug
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …

Marine pharmacology in 2016–2017: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral …

AMS Mayer, AJ Guerrero, AD Rodríguez… - Marine drugs, 2021 - mdpi.com
The review of the 2016–2017 marine pharmacology literature was prepared in a manner
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …

Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity

CP Harper, A Day, M Tsingos, E Ding… - Applied and …, 2024 - journals.asm.org
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly
associated with certain actinobacterial and proteobacterial lineages. These molecules have …

The biological and chemical diversity of tetramic acid compounds from marine-derived microorganisms

M Jiang, S Chen, J Li, L Liu - Marine Drugs, 2020 - mdpi.com
Tetramic acid (pyrrolidine-2, 4-dione) compounds, isolated from a variety of marine and
terrestrial organisms, have attracted considerable attention for their diverse, challenging …

Natural products as anthelmintics: safeguarding animal health

AA Salim, MS Butler, MAT Blaskovich… - Natural Product …, 2023 - pubs.rsc.org
Covering literature to December 2022 This review provides a comprehensive account of all
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …

[HTML][HTML] Characterisation of the Antibiotic Profile of Lysobacter capsici AZ78, an Effective Biological Control Agent of Plant Pathogenic Microorganisms

F Brescia, A Vlassi, A Bejarano, B Seidl… - Microorganisms, 2021 - mdpi.com
Determining the mode of action of microbial biocontrol agents plays a key role in their
development and registration as commercial biopesticides. The biocontrol rhizobacterium …

[HTML][HTML] Methods in microbial biodiscovery

AA Salim, ZG Khalil, AH Elbanna, T Wu, RJ Capon - Marine Drugs, 2021 - mdpi.com
This review presents an account of the microbial biodiscovery methodology developed and
applied in our laboratory at The University of Queensland, Institute for Molecular Bioscience …

Discovery and biosynthesis of pseudoamides reveal enzymatic cyclization of the polyene precursor to 5–5 bicyclic tetramate macrolactams

X Li, Q Liu, H Zou, J Luo, Y Jiao, H Wang, L Du… - ACS …, 2023 - ACS Publications
Polycyclic tetramate macrolactams (PoTeMs) comprise a family of pharmacologically
promising macrolactams that possess a tetramic acid moiety and various carbocyclic ring …

[HTML][HTML] The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and …

S Ul-Hasan, E Rodríguez-Román, AM Reitzel… - Toxicon: X, 2019 - Elsevier
Venom is a known source of novel antimicrobial natural products. The substantial,
increasing number of these discoveries have unintentionally culminated in the …

Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont

TY Nechitaylo, M Sandoval-Calderón, T Engl… - Proceedings of the …, 2021 - pnas.org
Genome erosion is a frequently observed result of relaxed selection in insect nutritional
symbionts, but it has rarely been studied in defensive mutualisms. Solitary beewolf wasps …