Mobility of plasmids
Plasmids are key vectors of horizontal gene transfer and essential genetic engineering tools.
They code for genes involved in many aspects of microbial biology, including detoxication …
They code for genes involved in many aspects of microbial biology, including detoxication …
Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera
Antibiotic resistance is a severe global threat for public health, causing around 700,000
deaths per year. Horizontal gene transfer (HGT) is one of the most significant pathways to …
deaths per year. Horizontal gene transfer (HGT) is one of the most significant pathways to …
Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow
RAF Wozniak, MK Waldor - Nature Reviews Microbiology, 2010 - nature.com
Integrative and conjugative elements (ICEs) are a diverse group of mobile genetic elements
found in both Gram-positive and Gram-negative bacteria. These elements primarily reside in …
found in both Gram-positive and Gram-negative bacteria. These elements primarily reside in …
Mating pair stabilization mediates bacterial conjugation species specificity
Bacterial conjugation mediates contact-dependent transfer of DNA from donor to recipient
bacteria, thus facilitating the spread of virulence and resistance plasmids. Here we describe …
bacteria, thus facilitating the spread of virulence and resistance plasmids. Here we describe …
Nucleases: diversity of structure, function and mechanism
W Yang - Quarterly reviews of biophysics, 2011 - cambridge.org
Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
Non-antibiotic pharmaceuticals promote the transmission of multidrug resistance plasmids through intra-and intergenera conjugation
Antibiotic resistance is a global threat to public health. The use of antibiotics at sub-inhibitory
concentrations has been recognized as an important factor in disseminating antibiotic …
concentrations has been recognized as an important factor in disseminating antibiotic …
Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them
Multidrug-resistant (MDR) bacteria have increased at an alarming rate over recent decades
and cause serious problems. The emergence of resistant infections caused by these …
and cause serious problems. The emergence of resistant infections caused by these …
The versatile bacterial type IV secretion systems
E Cascales, PJ Christie - Nature Reviews Microbiology, 2003 - nature.com
Bacteria use type IV secretion systems for two fundamental objectives related to
pathogenesis—genetic exchange and the delivery of effector molecules to eukaryotic target …
pathogenesis—genetic exchange and the delivery of effector molecules to eukaryotic target …
Conjugative plasmids: vessels of the communal gene pool
Comparative whole-genome analyses have demonstrated that horizontal gene transfer
(HGT) provides a significant contribution to prokaryotic genome innovation. The evolution of …
(HGT) provides a significant contribution to prokaryotic genome innovation. The evolution of …