Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Tau and neuroinflammation in Alzheimer's disease: Interplay mechanisms and clinical translation
Y Chen, Y Yu - Journal of neuroinflammation, 2023 - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …
neuropathological features are the extracellular neuritic plaques and intercellular …
Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …
[HTML][HTML] Glycogen synthase kinase-3 signaling in Alzheimer's disease
E Lauretti, O Dincer, D Praticò - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …
Nrf2: a dark horse in Alzheimer's disease treatment
Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …
GSK-3 and Tau: a key duet in Alzheimer's disease
CL Sayas, J Ávila - Cells, 2021 - mdpi.com
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …
Herpes simplex virus-1 in the brain: the dark side of a sneaky infection
ME Marcocci, G Napoletani, V Protto, O Kolesova… - Trends in …, 2020 - cell.com
Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …
Sha** the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases
L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …
[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine
MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …
GSK-3β, a pivotal kinase in Alzheimer disease
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …