Stroke: molecular mechanisms and therapies: update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

The influence of different types of diabetes on vascular complications

J Wei, J Tian, C Tang, X Fang, R Miao… - Journal of diabetes …, 2022 - Wiley Online Library
The final outcome of diabetes is chronic complications, of which vascular complications are
the most serious, which is the main cause of death for diabetic patients and the direct cause …

NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury

R Prakash, A Vyawahare, R Sakla, N Kumari… - ACS …, 2023 - ACS Publications
Ischemia–reperfusion (I/R) injury is a disease process that affects several vital organs. There
is widespread agreement that the NLRP3 inflammasome pathway plays a crucial role in the …

The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor …

O Golubnitschaja, J Polivka Jr, P Potuznik, M Pesta… - EPMA Journal, 2024 - Springer
Worldwide stroke is the second leading cause of death and the third leading cause of death
and disability combined. The estimated global economic burden by stroke is over US $891 …

pH-responsive multifunctional theranostic rapamycin-loaded nanoparticles for imaging and treatment of acute ischemic stroke

Y Cheng, A Cheng, Y Jia, L Yang, Y Ning… - … Applied Materials & …, 2021 - ACS Publications
Stroke is the second leading cause of death globally and the most common cause of severe
disability. Several barriers need to be addressed more effectively to treat stroke, including …

[HTML][HTML] DAMPs and RAGE pathophysiology at the acute phase of brain injury: an overview

B Balança, L Desmurs, J Grelier… - International Journal of …, 2021 - mdpi.com
Early or primary injury due to brain aggression, such as mechanical trauma, hemorrhage or
is-chemia, triggers the release of damage-associated molecular patterns (DAMPs) in the …

[HTML][HTML] pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain

SM Theparambil, G Begum, CR Rose - Cell Calcium, 2024 - Elsevier
Strict homeostatic control of pH in both intra-and extracellular compartments of the brain is
fundamentally important, primarily due to the profound impact of free protons ([H+]) on …

Tunable surface charge enables the electrostatic adsorption-controlled release of neuroprotective peptides from a hydrogel–nanoparticle drug delivery system

E Ho, Y Deng, D Akbar, K Da… - … Applied Materials & …, 2022 - ACS Publications
We exploit the electrostatic interactions between the positively charged neuroprotective
peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), and negatively charged …

Recent advances in targeted nanotherapies for ischemic stroke

J Liao, Y Li, Y Luo, S Meng, C Zhang… - Molecular …, 2022 - ACS Publications
Ischemic stroke (IS) is a severe neurological disease caused by the narrowing or occlusion
of cerebral blood vessels and is known for high morbidity, disability, and mortality rates …

[HTML][HTML] Ferroptosis: Emerging role in diseases and potential implication of bioactive compounds

GT Patanè, S Putaggio, E Tellone, D Barreca… - International Journal of …, 2023 - mdpi.com
Ferroptosis is a form of cell death that is distinguished from other types of death for its
peculiar characteristics of death regulated by iron accumulation, increase in ROS, and lipid …