The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

Background Random forest (RF) is a machine-learning method that generally works well
with high-dimensional problems and allows for nonlinear relationships between predictors; …

Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene
expression levels. Mitochondrial function is essential to provide the intermediate metabolites …

Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …

Epidemiologic and clinical studies suggest that elevated triglyceride levels are a biomarker
of cardiovascular (CV) risk. Consistent with these findings, recent genetic evidence from …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …