Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

Antibiotic resistance in the environment

DGJ Larsson, CF Flach - Nature Reviews Microbiology, 2022 - nature.com
Antibiotic resistance is a global health challenge, involving the transfer of bacteria and
genes between humans, animals and the environment. Although multiple barriers restrict the …

Evolution of triclosan resistance modulates bacterial permissiveness to multidrug resistance plasmids and phages

QE Yang, X Ma, M Li, M Zhao, L Zeng, M He… - Nature …, 2024 - nature.com
The horizontal transfer of plasmids has been recognized as one of the key drivers for the
worldwide spread of antimicrobial resistance (AMR) across bacterial pathogens. However …

Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges

AQ Nguyen, HP Vu, LN Nguyen, Q Wang… - Science of the Total …, 2021 - Elsevier
Antimicrobial resistance (AMR) is a growing threat to human and animal health. Progress in
molecular biology has revealed new and significant challenges for AMR mitigation given the …

Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids

S Redondo-Salvo, R Fernández-López, R Ruiz… - Nature …, 2020 - nature.com
Plasmids can mediate horizontal gene transfer of antibiotic resistance, virulence genes, and
other adaptive factors across bacterial populations. Here, we analyze genomic composition …

Microplastic pollution increases gene exchange in aquatic ecosystems

M Arias-Andres, U Klümper, K Rojas-Jimenez… - Environmental …, 2018 - Elsevier
Pollution by microplastics in aquatic ecosystems is accumulating at an unprecedented scale,
emerging as a new surface for biofilm formation and gene exchange. In this study, we …

[HTML][HTML] Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

DGJ Larsson, A Andremont, J Bengtsson-Palme… - Environment …, 2018 - Elsevier
There is growing understanding that the environment plays an important role both in the
transmission of antibiotic resistant pathogens and in their evolution. Accordingly …

Phthalates promote dissemination of antibiotic resistance genes: An overlooked environmental risk

J Wu, JH Zhou, DF Liu, J Wu, RL He… - Environmental …, 2023 - ACS Publications
Plastics–microorganism interactions have aroused growing environmental and ecological
concerns. However, previous studies concentrated mainly on the direct interactions and paid …

Non-antibiotic pharmaceuticals promote the transmission of multidrug resistance plasmids through intra-and intergenera conjugation

Y Wang, J Lu, S Zhang, J Li, L Mao, Z Yuan… - The ISME …, 2021 - academic.oup.com
Antibiotic resistance is a global threat to public health. The use of antibiotics at sub-inhibitory
concentrations has been recognized as an important factor in disseminating antibiotic …

[HTML][HTML] Interphylum dissemination of NDM-5-positive plasmids in hospital wastewater from Fuzhou, China: a single-centre, culture-independent, plasmid transmission …

QE Yang, X Ma, L Zeng, Q Wang, M Li, L Teng… - The Lancet …, 2024 - thelancet.com
Background The global spread of plasmid-borne carbapenem resistance is an ongoing
public health challenge; however, the nature of such horizontal gene transfer events among …