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Acute lymphoblastic leukaemia
L Pagliaro, SJ Chen, D Herranz, C Mecucci… - Nature Reviews …, 2024 - nature.com
Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …
DNA methylation in mammalian development and disease
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
Whole-genome dna methylation profiling of intrahepatic cholangiocarcinoma reveals prognostic subtypes with distinct biological drivers
H Liao, X Chen, H Wang, Y Lin, L Chen, K Yuan… - Cancer …, 2024 - aacrjournals.org
Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent primary liver cancer.
Although the genetic characterization of iCCA has led to targeted therapies for treating …
Although the genetic characterization of iCCA has led to targeted therapies for treating …
Classification and risk stratification in T-lineage acute lymphoblastic leukemia
Cure rates for patients with acute lymphoblastic leukemia (ALL) have improved markedly in
recent decades, in part due to risk stratification incorporating leukemia genomics, response …
recent decades, in part due to risk stratification incorporating leukemia genomics, response …
Comprehensive genomic analysis reveals molecular heterogeneity in pediatric ALK-positive anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) is a mature T-cell lymphoma that accounts for 10–
15% of childhood lymphomas. Despite the observation that more than 90% of pediatric …
15% of childhood lymphomas. Despite the observation that more than 90% of pediatric …
Targeting DNA methylation in leukemia, myelodysplastic syndrome, and lymphoma: a potential diagnostic, prognostic, and therapeutic tool
L Kalinkova, A Sevcikova, V Stevurkova… - International Journal of …, 2022 - mdpi.com
DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …
malignancies. The methylation process is controlled by specific DNA methyl transferases …