Childhood obesity from the genes to the epigenome

S Sivakumar, D Lama, N Rabhi - Frontiers in Endocrinology, 2024 - frontiersin.org
The prevalence of obesity and its associated comorbidities has surged dramatically in recent
decades. Especially concerning is the increased rate of childhood obesity, resulting in …

[HTML][HTML] Model construction and clinical therapeutic potential of engineered cardiac organoids for cardiovascular diseases

Y Wang, Y Hou, T Hao… - Biomaterials …, 2024 - pmc.ncbi.nlm.nih.gov
Cardiovascular diseases cause significant morbidity and mortality worldwide. Engineered
cardiac organoids are being developed and used to replicate cardiac tissues supporting …

Small left ventricle in patients with atrial fibrillation is associated with increased cardiovascular risk

M Li, L Ren, L He, Y Lai, J Wang, S Li, X Peng… - Journal of the American …, 2024 - jacc.org
Background It is still unclear whether small left ventricle (LV) is an adverse structural
prognostic feature in patients with atrial fibrillation (AF). Objectives The purpose of this study …

Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis

H Fu, T Xu, W Zhao, L Jiang, S Shan - Frontiers in Microbiology, 2024 - frontiersin.org
Background Androgenetic alopecia (AGA) is the most common type of androgen-associated
hair loss. Previous studies have indicated an association between the gut microbiota and …

Prenatal exposure to metal mixtures, body mass index trajectories in early life and effect modifiers: Insights from a prospective birth cohort study

C Yang, X Sun, H Liu, L Yu, S Xu, A Zhou… - Journal of Hazardous …, 2024 - Elsevier
Current scientific knowledge is insufficient on the effects of metal mixtures on early life
growth trajectories. This study included 7118 mother-infant pairs from a Chinese birth cohort …

Is lower birthweight truly causal for increased cardiovascular risk?

NM Warrington, G Wang, TA Bond - European Heart Journal, 2024 - academic.oup.com
Ardissino et al. 1 present a Mendelian randomization (MR) study suggesting that lower
birthweight is causal for increased risk of coronary artery disease. We argue that this …

Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction

A Schuermans, AB Pournamdari, J Lee… - Nature Cardiovascular …, 2024 - nature.com
Cardiac diseases represent common highly morbid conditions for which molecular
mechanisms remain incompletely understood. Here we report the analysis of 1,459 protein …

Genetic analyses of birthweight and cardiovascular disease

M Ardissino, S Burgess, FS Ng - European heart journal, 2024 - academic.oup.com
This commentary refers to 'Birth weight influences cardiac structure, function, and disease
risk: evidence of a causal association', by M. Ardissino et al., https://doi …

Small left ventricular chamber size and mortality in a large general population

D Leibowitz, D Zwas, O Amir, I Gotsman - The American Journal of …, 2025 - Elsevier
Enlargement of the left ventricle (LV) is an important marker of adverse cardiac remodeling
and poor prognosis. Previous studies demonstrated increased cardiovascular risk in small …

Multi‐Organ Phenotypes of Offspring Born Following Hypertensive Disorders of Pregnancy: A Systematic Review

PD Sattwika, A Schuermans, HR Cutler… - Journal of the …, 2024 - ahajournals.org
Background Hypertensive pregnancies are associated with an increased risk of
cardiovascular and neurological diseases in the offspring during later life. However, less is …