Recent advancement of piperidine moiety in treatment of cancer-A review

P Goel, O Alam, MJ Naim, F Nawaz, M Iqbal… - European journal of …, 2018 - Elsevier
Piperidine is an important pharmacophore, a privileged scaffold and an excellent
heterocyclic system in the field of drug discovery which provides numerous opportunities in …

1, 8‐Naphthyridine derivatives: A review of multiple biological activities

A Madaan, R Verma, V Kumar, AT Singh… - Archiv der …, 2015 - Wiley Online Library
The 1, 8‐naphthyridine group of compounds have gained special attention of researchers
on account of their demonstrating a variety of interesting biological activities. A wide range of …

Ultrasound-based synthesis, SC-XRD, NMR, DFT, HSA of new Schiff bases derived from 2-aminopyridine: Experimental and theoretical studies

H Kargar, R Behjatmanesh-Ardakani… - Journal of Molecular …, 2021 - Elsevier
The present work is related to the rapid and efficient preparation of Schiff bases (1 and 2) by
reaction of 2-aminopyridine derivatives with 3-ethoxysalicylaldehyde under ultrasonic …

Synthesis, characterization, molecular docking and cytotoxicity studies on N-benzyl-2-isonicotinoylhydrazine-1-carbothioamide and its metal complexes

MH Abdel-Rhman, MA Hussien, HM Mahmoud… - Journal of Molecular …, 2019 - Elsevier
Abstract N-benzyl-2-isonicotinoylhydrazine-1-carbothioamide (H 3 L) and its complexes with
Co (II), Ni (II), Cu (II) and Zn (II) have been synthesized. The metal complexes have been …

Anticancer activity of Mannich bases: a review of recent literature

G Roman - ChemMedChem, 2022 - Wiley Online Library
This report summarizes the latest published data on the antiproliferative action and cytotoxic
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …

Structure characterization, DNA binding, molecular docking and antitumor activity of manganese isothiocyanate complex with neocuproine ligand

MM El-bendary, A Akhdhar, D Domyati, EMM Ali… - Polyhedron, 2025 - Elsevier
The novel complex of [Mn (SCN) 2 (neo) 2],(1) was isolated at room temperature by mixing
aqueous solutions of potassium thiocyanate and 2, 9-dimethyl-1, 10-phenanthroline …

Synthesis, Spectral, Modeling, Docking and Cytotoxicity Studies on 2‐(2‐aminobenzoyl)‐N‐ethylhydrazine‐1‐carbothioamide and its divalent metal complexes

NM Hosny, MA Hussien, R Motawa… - Applied …, 2020 - Wiley Online Library
2‐(2‐aminobenzoyl)‐N‐ethylhydrazine‐1‐carbothioamide (H3L) and its Cu (II), Co (II), Ni (II)
and Zn (II) complexes have been synthesized. The structures of the isolated compounds …

Biological Validation of Novel Polysubstituted Pyrazole Candidates with in Vitro Anticancer Activities

HH Fahmy, NM Khalifa, MMF Ismail, HM El-Sahrawy… - Molecules, 2016 - mdpi.com
With the aim of develo** novel antitumor scaffolds, a novel series of polysubstituted
pyrazole derivatives linked to different nitrogenous heterocyclic ring systems at the C-4 …

Transition metal complexes of N'-(2-cyanoacetyl) nicotinohydrazide: Synthesis, structural and anticancer activity studies

MH Abdel-Rhman, G Samir, MA Hussien, NM Hosny - Polyhedron, 2024 - Elsevier
On reacting the nicotinic hydrazide with 1-cyanoacetyl-3, 5-dimethylpyrazole, a new ligand,
N'-(2-cyanoacetyl) nicotinohydrazide (H 2 L), was produced and characterized using diverse …

Exploring novel NH-form resorcinol-based schiff base and its metal complexes: Synthesis, characterization, cytotoxic activity, molecular docking and ADME studies

ES Aazam, M Majrashi, MA Hussien - Heliyon, 2024 - cell.com
The research investigates the cytotoxic effects of the stable NH-form of a resorcinol-based
Schiff base (HL) and its metal complexes (Zn (II), Cd (II), Cu (II), Ni (II)) on MCF-7 breast …