AMPK and the Endocrine Control of Metabolism

LK Townsend, GR Steinberg - Endocrine reviews, 2023‏ - academic.oup.com
Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases

EJ Tillman, T Rolph - Frontiers in endocrinology, 2020‏ - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

[HTML][HTML] The impact of moderate-intensity continuous or high-intensity interval training on adipogenesis and browning of subcutaneous adipose tissue in obese male …

M Khalafi, H Mohebbi, ME Symonds, P Karimi, A Akbari… - Nutrients, 2020‏ - mdpi.com
This study compares the effect of two types of exercise training, ie, moderate-intensity
continuous training (MICT) or high-intensity interval training (HIIT) on the browning of …

Fibroblast growth factor 21—metabolic role in mice and men

H Staiger, M Keuper, L Berti… - Endocrine …, 2017‏ - academic.oup.com
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Emerging role of AMPK in brown and beige adipose tissue (BAT): implications for obesity, insulin resistance, and type 2 diabetes

EM Desjardins, GR Steinberg - Current diabetes reports, 2018‏ - Springer
Abstract Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at
alarming rates, demanding the development of additional classes of therapeutics to further …

Fibroblast growth factor 21 in non-alcoholic fatty liver disease

B Tucker, H Li, X Long, KA Rye, KL Ong - Metabolism, 2019‏ - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies ranging
from uncomplicated hepatic fat accumulation to a state of lobular inflammation and …

Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes

HS Lee, CU Heo, YH Song, K Lee, CI Choi - Archives of Pharmacal …, 2023‏ - Springer
Induction of the brown adipocyte-like phenotype in white adipocytes (fat browning) is
considered a promising therapeutic strategy to treat obesity. Naringin, a citrus flavonoid, has …

Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study

Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022‏ - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

[HTML][HTML] The role of AMPK signaling in brown adipose tissue activation

JI van der Vaart, MR Boon, RH Houtkooper - Cells, 2021‏ - mdpi.com
Obesity is becoming a pandemic, and its prevalence is still increasing. Considering that
obesity increases the risk of develo** cardiometabolic diseases, research efforts are …

[HTML][HTML] FGF19 and FGF21: In NASH we trust

S Talukdar, A Kharitonenkov - Molecular Metabolism, 2021‏ - Elsevier
Abstract Fibroblast Growth Factors 19 and 21 (FGF19 and FGF21) are novel endocrine
messengers that regulate multiple aspects of energy homeostasis. The magnitude and …