The adolescent brain and age-related behavioral manifestations
LP Spear - Neuroscience & biobehavioral reviews, 2000 - Elsevier
To successfully negotiate the developmental transition between youth and adulthood,
adolescents must maneuver this often stressful period while acquiring skills necessary for …
adolescents must maneuver this often stressful period while acquiring skills necessary for …
Compensatory mechanisms in Parkinson's disease: circuits adaptations and role in disease modification
The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway
Human idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder
that is primarily characterized by degeneration of the dopaminergic neurons of the …
that is primarily characterized by degeneration of the dopaminergic neurons of the …
Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system
Recombinant adeno-associated viral vectors display efficient tropism for transduction of the
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …
Functional changes of the basal ganglia circuitry in Parkinson's disease
The basal ganglia circuitry processes the signals that flow from the cortex, allowing the
correct execution of voluntary movements. In Parkinson's disease, the degeneration of …
correct execution of voluntary movements. In Parkinson's disease, the degeneration of …
In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA)
neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional …
neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional …
Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors
Adolescence is an evolutionarily conserved developmental phase characterized by
hormonal, physiological, neural and behavioral alterations evident widely across …
hormonal, physiological, neural and behavioral alterations evident widely across …
Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications
The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's
disease (PD) for over 40 years. However, the response to this treatment changes with …
disease (PD) for over 40 years. However, the response to this treatment changes with …
Noradrenergic mechanisms in neurodegenerative diseases: a theory
A deficiency in the noradrenergic system of the brain, originating largely from cells in the
locus coeruleus (LC), is theorized to play a critical role in the progression of a family of …
locus coeruleus (LC), is theorized to play a critical role in the progression of a family of …
Dopamine-dependent plasticity of corticostriatal synapses
Knowledge of the effect of dopamine on corticostriatal synaptic plasticity has advanced
rapidly over the last 5 years. We consider this new knowledge in relation to three factors …
rapidly over the last 5 years. We consider this new knowledge in relation to three factors …