During the last 30 years, deep brain stimulation (DBS) has evolved into the clinical standard
of care as a highly effective treatment for advanced Parkinson's disease. Careful patient …

Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD).
The progression and management of tremor in PD can be challenging, as response to …

Ventral intermediate thalamic deep brain stimulation is a standard therapy for the treatment
of medically refractory essential tremor and tremor-dominant Parkinson's disease. Despite …

Parkinson's resting tremor is related to altered cerebral activity in the basal ganglia and the
cerebello-thalamo-cortical circuit. Although Parkinson's disease is characterized by …

L-DOPA is still the most effective pharmacological therapy for the treatment of motor
symptoms in Parkinson's disease (PD) almost four decades after it was first used. Deep …

Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …

Focal direct-to-brain neuromodulation approaches, such as repetitive transcranial magnetic
stimulation (TMS), deep brain stimulation (DBS) and ablative techniques, hold tremendous …

Background The neuroanatomical substrates of Parkinson's disease (PD) with tremor‐
dominance (TD) and those with non‐tremor dominance (nTD), postural instability and gait …

The characteristics of the Parkinson's disease tremor reported previously are not applicable
to the full spectrum of severity. The characteristics of high-and low-amplitude tremors differ in …

Background Essential tremor (ET) can be debilitating. Treatments for ET include beta-
blockers and surgical interventions. Low-intensity focused ultrasound (LIFU) may offer an …