Cytokines in sepsis: potent immunoregulators and potential therapeutic targets—an updated view
Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …
Evolving complexity of MIF signaling
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease
Parthanatos-associated apoptosis-inducing factor (AIF) nuclease (PAAN), also known as
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …
The immunobiology of MIF: function, genetics and prospects for precision medicine
I Kang, R Bucala - Nature Reviews Rheumatology, 2019 - nature.com
The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by
data showing that common functional polymorphisms in MIF are associated with disease …
data showing that common functional polymorphisms in MIF are associated with disease …
Role of MIF cytokine/CD74 receptor pathway in protecting against injury and promoting repair
Wound healing after an injury is essential for life. An in-depth understanding of the healing
process is necessary to ultimately improve the currently limited treatment options for patients …
process is necessary to ultimately improve the currently limited treatment options for patients …
The biological function and significance of CD74 in immune diseases
H Su, N Na, X Zhang, Y Zhao - Inflammation Research, 2017 - Springer
Abstract CD74 (MHC class II invariant chain, Ii) is a non-polymorphic type II transmembrane
glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a …
glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a …
MIF-dependent control of tumor immunity
JT Noe, RA Mitchell - Frontiers in immunology, 2020 - frontiersin.org
Initially identified as a T lymphocyte-elicited inhibitor of macrophage motility, macrophage
migration inhibitory factor (MIF) has since been found to be expressed by nearly every …
migration inhibitory factor (MIF) has since been found to be expressed by nearly every …
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model
PV Tilstam, W Schulte, T Holowka… - The Journal of …, 2021 - Am Soc Clin Investig
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …
Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus
JB Bilsborrow, E Doherty, PV Tilstam… - Expert opinion on …, 2019 - Taylor & Francis
Introduction. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …