Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy
Over the last decade, there has been increasing evidence that hyperactivation of the
mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical …
mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical …
Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …
global population continues to climb with improved life expectancy. At present, more than 30 …
Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
Focal cortical dysplasia type II (FCDII) is a sporadic developmental malformation of the
cerebral cortex characterized by dysmorphic neurons, dyslamination and medically …
cerebral cortex characterized by dysmorphic neurons, dyslamination and medically …
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia
Malformations of cortical development containing dysplastic neuronal and glial elements,
including hemimegalencephaly and focal cortical dysplasia, are common causes of …
including hemimegalencephaly and focal cortical dysplasia, are common causes of …
Noninflammatory changes of microglia are sufficient to cause epilepsy
Microglia are well known to play a critical role in maintaining brain homeostasis. However,
their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated …
their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated …
Autism spectrum disorder and epilepsy: disorders with a shared biology
BH Lee, T Smith, AR Paciorkowski - Epilepsy & Behavior, 2015 - Elsevier
There is an increasing recognition of clinical overlap in patients presenting with epilepsy
and autism spectrum disorder (ASD), and a great deal of new information regarding the …
and autism spectrum disorder (ASD), and a great deal of new information regarding the …
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
F Alyu, M Dikmen - Acta neuropsychiatrica, 2017 - cambridge.org
ObjectiveEpilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis
Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …
Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy
MR Winawer, NG Griffin, J Samanamud… - Annals of …, 2018 - Wiley Online Library
Objective Somatic variants are a recognized cause of epilepsy‐associated focal
malformations of cortical development (MCD). We hypothesized that somatic variants may …
malformations of cortical development (MCD). We hypothesized that somatic variants may …
Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …