The role of inflammation in the development of epilepsy
A Rana, AE Musto - Journal of neuroinflammation, 2018 - Springer
Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …
with a history of previous lesions in the nervous system. Impaired regulation of the activation …
The functional significance behind expressing two IL–8 receptor types on PMN
The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …
has led to interest in whether each receptor type contributes to unique functions. PMN are …
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
Background G protein coupled receptors (GPCRs) are one of the most widely studied gene
superfamilies. Thousands of GPCR research studies have utilized heterologous expression …
superfamilies. Thousands of GPCR research studies have utilized heterologous expression …
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma
Evasion of host immune responses is well documented for viruses and may also occur
during tumor immunosurveillance. The mechanisms involve alterations in MHC class I …
during tumor immunosurveillance. The mechanisms involve alterations in MHC class I …
Biased and g protein-independent signaling of chemokine receptors
A Steen, O Larsen, S Thiele… - Frontiers in …, 2014 - frontiersin.org
Biased signaling or functional selectivity occurs when a 7TM-receptor preferentially activates
one of several available pathways. It can be divided into three distinct forms: ligand bias …
one of several available pathways. It can be divided into three distinct forms: ligand bias …
Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function
RA Colvin, GSV Campanella, J Sun… - Journal of Biological …, 2004 - ASBMB
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T
cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and …
cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and …
New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model
Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …
and dysregulated CKR signaling underpins numerous disease processes of the immune …
Chemokine receptor internalization and intracellular trafficking
NF Neel, E Schutyser, J Sai, GH Fan… - Cytokine & growth factor …, 2005 - Elsevier
The internalization and intracellular trafficking of chemokine receptors have important
implications for the cellular responses elicited by chemokine receptors. The major pathway …
implications for the cellular responses elicited by chemokine receptors. The major pathway …
Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer
CXCL8 (also known as IL-8) activates CXCR1 and CXCR2 to mediate neutrophil recruitment
and trigger cytotoxic effect at sites of infection. Under physiological conditions, CXCL8 could …
and trigger cytotoxic effect at sites of infection. Under physiological conditions, CXCL8 could …
CXCR2 antagonists for the treatment of pulmonary disease
RW Chapman, JE Phillips, RW Hipkin… - Pharmacology & …, 2009 - Elsevier
Chemokines have long been implicated in the initiation and amplification of inflammatory
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …