The health digital twin to tackle cardiovascular disease—a review of an emerging interdisciplinary field

G Coorey, GA Figtree, DF Fletcher, VJ Snelson… - NPJ digital …, 2022 - nature.com
Potential benefits of precision medicine in cardiovascular disease (CVD) include more
accurate phenoty** of individual patients with the same condition or presentation, using …

[HTML][HTML] Mental stress and cardiovascular health—Part I

F Vancheri, G Longo, E Vancheri… - Journal of clinical medicine, 2022 - mdpi.com
Epidemiological studies have shown that a substantial proportion of acute coronary events
occur in individuals who lack the traditional high-risk cardiovascular (CV) profile. Mental …

Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data

GA Figtree, ST Vernon, N Hadziosmanovic… - The Lancet, 2021 - thelancet.com
Background In cardiovascular disease, prevention strategies targeting standard modifiable
cardiovascular risk factors (SMuRFs; hypertension, diabetes, hypercholesterolaemia, and …

Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: results from a global meta-analysis of 1,285,722 patients

G Kong, YH Chin, B Chong, RSJ Goh, OZH Lim… - International journal of …, 2023 - Elsevier
Background Standard modifiable cardiovascular risk factors (SMuRF), comprising diabetes,
hyperlipidemia, hypertension, and smoking, are used for risk stratification in acute coronary …

Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study

SMJ Cho, S Koyama, MC Honigberg… - European heart …, 2023 - academic.oup.com
Aims Complications of coronary artery disease (CAD) represent the leading cause of death
among adults globally. This study examined the associations and clinical utilities of genetic …

ST‐segment–elevation myocardial infarction (STEMI) patients without standard modifiable cardiovascular risk factors—how common are they, and what are their …

ST Vernon, S Coffey, M D'Souza, CK Chow… - Journal of the …, 2019 - ahajournals.org
Background Programs targeting the standard modifiable cardiovascular risk factors
(SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to …

Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review

GA Figtree, ST Vernon, JA Harmer, MP Gray… - Journal of the American …, 2023 - jacc.org
Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors
(SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD) …

Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

NS Nurmohamed, AR van Rosendael… - European heart …, 2024 - academic.oup.com
Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely
to an individual's complex pathophysiological predisposition to atherosclerosis and provide …

A call to action for new global approaches to cardiovascular disease drug solutions

GA Figtree, K Broadfoot, B Casadei, R Califf… - European heart …, 2021 - academic.oup.com
Whilst we continue to wrestle with the immense challenge of implementing equitable access
to established evidence-based treatments, substantial gaps remain in our pharmacotherapy …

Noninvasive plaque imaging to accelerate coronary artery disease drug development

GA Figtree, PD Adamson, C Antoniades… - Circulation, 2022 - ahajournals.org
Coronary artery disease (CAD) remains the leading cause of adult mortality globally.
Targeting known modifiable risk factors has had substantial benefit, but there remains a …