A History of the Development of Brucella Vaccines

ED Avila-Calderón, A Lopez-Merino… - BioMed research …, 2013 - Wiley Online Library
Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several
decades, much research has been performed to develop safer Brucella vaccines to control …

Towards a Brucella vaccine for humans

SD Perkins, SJ Smither, HS Atkins - FEMS microbiology reviews, 2010 - academic.oup.com
There is currently no licensed vaccine for brucellosis in humans. Available animal vaccines
may cause disease and are considered unsuitable for use in humans. However, the …

Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4+ and CD8+ T Cells as Well as Systemic and …

KA Pasquevich, SM Estein, CG Samartino… - Infection and …, 2009 - journals.asm.org
Available vaccines against Brucella spp. are live attenuated Brucella strains. In order to
engineer a better vaccine to be used in animals and humans, our laboratory aims to develop …

An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice

KA Pasquevich, AE Ibanez, LM Coria… - PloS one, 2011 - journals.plos.org
As Brucella infections occur mainly through mucosal surfaces, the development of mucosal
administered vaccines could be radical for the control of brucellosis. In this work we …

Vaccination schedules in small ruminant farms

D Lacasta, LM Ferrer, JJ Ramos, JM González… - Veterinary …, 2015 - Elsevier
Abstract Development and implementation of health management plans is the cornerstone
of profitable farms; prevention of microbial diseases by means of vaccination is an integral …

Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c mice

MV Delpino, SM Estein, CA Fossati, PC Baldi… - Vaccine, 2007 - Elsevier
The immunogenicity and protective efficacy of recombinant SurA (rSurA) and rDnaK from
Brucella spp. were evaluated in BALB/c mice. Immunization with rSurA in adjuvant induced …

Protein-based Nanoparticle Vaccine approaches against Infectious diseases

D Tapia, A Reyes-Sandoval… - Archives of Medical …, 2023 - Elsevier
The field of vaccine development has seen an increase in the number of rationally designed
technologies that increase effectiveness against vaccine-resistant pathogens, while not …

When the Going Gets Rough: The Significance of Brucella Lipopolysaccharide Phenotype in Host–Pathogen Interactions

LW Stranahan, AM Arenas-Gamboa - Frontiers in Microbiology, 2021 - frontiersin.org
Brucella is a facultatively intracellular bacterial pathogen and the cause of worldwide
zoonotic infections, infamous for its ability to evade the immune system and persist …