SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in
the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

Parkinson's disease (PD) is the second most common neurodegenerative disease. About
2% of the population above the age of 60 is affected by the disease. The pathological …

Copy number mutations implicate excess production of α-synuclein as a possibly causative
factor in Parkinson's disease (PD). Using an unbiased screen targeting endogenous gene …

Neurons rely mostly on mitochondria for the production of ATP and Ca2+ homeostasis. As
sub-compartmentalized cells, they have different pools of mitochondria in each compartment …

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …