[HTML][HTML] Effects of psychological, environmental and physical stressors on the gut microbiota

JP Karl, AM Hatch, SM Arcidiacono… - Frontiers in …, 2018 - frontiersin.org
Stress, a ubiquitous part of daily human life, has varied biological effects which are
increasingly recognized as including modulation of commensal microorganisms residing in …

Clocking in to immunity

C Scheiermann, J Gibbs, L Ince… - Nature Reviews …, 2018 - nature.com
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

H Choi, MC Rao, EB Chang - Nature Reviews Gastroenterology & …, 2021 - nature.com
Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …

[HTML][HTML] When rhythms meet the blues: circadian interactions with the microbiota-gut-brain axis

EM Teichman, KJ O'Riordan, CGM Gahan, TG Dinan… - Cell metabolism, 2020 - cell.com
The microbiota-gut-brain axis encompasses a bidirectional mode of communication
between the microorganisms residing in our gut, and our brain function and behavior. The …

Reserve stem cells in intestinal homeostasis and injury

ED Bankaitis, A Ha, CJ Kuo, ST Magness - Gastroenterology, 2018 - Elsevier
Renewal of the intestinal epithelium occurs approximately every week and requires a careful
balance between cell proliferation and differentiation to maintain proper lineage ratios and …

Circadian clocks in the digestive system

A Segers, I Depoortere - Nature Reviews Gastroenterology & …, 2021 - nature.com
Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …

Circadian-regulated cell death in cardiovascular diseases

I Rabinovich-Nikitin, B Lieberman, TA Martino… - Circulation, 2019 - ahajournals.org
Background: Over the past several years, a variety of human and animal studies have
shown that circadian clocks regulate biological cardiovascular rhythms in both health and …

Adaptive immunity, chronic inflammation and the clock

KJ Gray, JE Gibbs - Seminars in Immunopathology, 2022 - Springer
The adaptive arm of the immune system facilitates recognition of specific foreign pathogens
and, via the action of T and B lymphocytes, induces a fine-tuned response to target the …

[HTML][HTML] The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation

K Stokes, M Nunes, C Trombley, DEFL Flôres… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Circadian rhythms are daily physiological oscillations driven by the
circadian clock: a 24-hour transcriptional timekeeper that regulates hormones, inflammation …

Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty …

Y Shimizu, R Yamamura, Y Yokoi, T Ayabe… - Gut …, 2023 - Taylor & Francis
Sleep is essential for our health. Short sleep is known to increase disease risks via
imbalance of intestinal microbiota, dysbiosis. However, mechanisms by which short sleep …