Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Mitochondria provide numerous essential functions for cells and their dysfunction leads to a
variety of diseases. Thus, obtaining a complete mitochondrial proteome should be a crucial …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …

Most mitochondrial proteins possess N-terminal presequences that are required for targeting
and import into the organelle. Upon import, presequences are cleaved off by matrix …