Vitiligo is a multifactorial reversible skin disorder characterized by distinct white patches that
result from melanocyte destruction. Activated CXCR3+ CD8+ T cells promote melanocyte …

Breast cancer is a common malignancy among women worldwide. Regardless of the
economic status of a country, breast cancer poses a burden in prevention, diagnosis and …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in
numerous cancer types, including more than 40% of breast cancers. In contrast to tight …

Pancreatic cancer is expected to be the second deadliest malignancy in the USA by 2020.
The survival rates for patients with other gastrointestinal malignancies have increased …

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour
microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

1282 tandem kinase-homologous domains at the C-terminus. The first is a noncatalytic
regulatory domain, whereas the second has tyrosine kinase activity. In mammals, the JAK …

Reactive oxygen species (ROS), whether produced endogenously as a consequence of
normal cell functions or derived from external sources, pose a constant threat to cells living …