Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …

Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral
learning and memory with rich computational properties. However, the relationship between …

The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

We describe convergent evidence from transcriptomics, morphology, and physiology for a
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus …

The size and shape of dendrites and axons are strong determinants of neuronal information
processing. Our knowledge on neuronal structure and function is primarily based on brains …

Highlights•Adult human synapses show long-term potentiation and depression.•Activity-
dependent rules for associative plasticity have broad temporal windows.•Synaptic plasticity …

Associative memory enables the encoding and retrieval of relations between different
stimuli. To better understand its neural basis, we investigated whether associative memory …

The advanced cognitive capabilities of the human brain are often attributed to our recently
evolved neocortex. However, it is not known whether the basic building blocks of the human …

Synaptic transmission constitutes the primary mode of communication between neurons. It is
extensively studied in rodent but not human neocortex. We characterized synaptic …