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Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: from mechanisms to therapeutics
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …
discouragingly low survival rate and few effective treatments. An important function of the …
miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools
Over the last decades, microRNAs (miRNAs) have emerged as important molecules
associated with the regulation of gene expression in humans and other organisms …
associated with the regulation of gene expression in humans and other organisms …
A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasion
HG Møller, AP Rasmussen, HH Andersen… - Molecular …, 2013 - Springer
Glioblastoma multiforme (GBM) is an incurable form of brain cancer with a very poor
prognosis. Because of its highly invasive nature, it is impossible to remove all tumor cells …
prognosis. Because of its highly invasive nature, it is impossible to remove all tumor cells …
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …
mechanisms, gene network analysis provides a complementary framework in which to tackle …
Profiling of circulating microRNAs: from single biomarkers to re-wired networks
The recent discovery that microRNAs (miRNAs) are present in the circulation sparked
interest in their use as potential biomarkers. In this review, we will summarize the latest …
interest in their use as potential biomarkers. In this review, we will summarize the latest …
miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer
MicroRNAs (miRNAs) control cell cycle progression by targeting the transcripts encoding for
cyclins, CDKs and CDK inhibitors, such as p27 KIP1 (p27). p27 expression is controlled by …
cyclins, CDKs and CDK inhibitors, such as p27 KIP1 (p27). p27 expression is controlled by …
A cerebrospinal fluid microRNA signature as biomarker for glioblastoma
JC Akers, W Hua, H Li, V Ramakrishnan, Z Yang… - …, 2017 - pmc.ncbi.nlm.nih.gov
Purpose To develop a cerebrospinal fluid (CSF) miRNA diagnostic biomarker for
glioblastoma. Experimental Design Glioblastoma tissue and matched CSF from the same …
glioblastoma. Experimental Design Glioblastoma tissue and matched CSF from the same …
The pathobiology of collagens in glioma
LS Payne, PH Huang - Molecular Cancer Research, 2013 - aacrjournals.org
Malignant gliomas are characterized by a diffuse infiltration into the surrounding brain
parenchyma. Infiltrating glioma cells exist in close proximity with components of the tumor …
parenchyma. Infiltrating glioma cells exist in close proximity with components of the tumor …
miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways
Z Liu, Z Jiang, J Huang, S Huang… - International …, 2014 - spandidos-publications.com
Epidermal growth factor receptor (EGFR) signaling regulates glioblastoma cell proliferation,
survival, migration and invasion and plays a key role in tumor progression. We show that …
survival, migration and invasion and plays a key role in tumor progression. We show that …
Uncovering microRNA and transcription factor mediated regulatory networks in glioblastoma
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in humans.
Recent studies revealed that patterns of microRNA (miRNA) expression in GBM tissue …
Recent studies revealed that patterns of microRNA (miRNA) expression in GBM tissue …