Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
Predictive processing: a canonical cortical computation
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …
understanding cortical function in the context of emerging evidence, with a focus on sensory …
[HTML][HTML] A transcriptomic axis predicts state modulation of cortical interneurons
Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …
Where is the error? Hierarchical predictive coding through dendritic error computation
Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …
[HTML][HTML] Cortical somatostatin interneuron subtypes form cell-type-specific circuits
The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgrou**s gloss over the molecular, morphological, and circuit specificity of …
broad subgrou**s gloss over the molecular, morphological, and circuit specificity of …
GABAergic interneurons in the neocortex: from cellular properties to circuits
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …
Neuromodulation of brain state and behavior
Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …
between repeated presentation of identical stimuli or trials. Recent results in humans and …
Illuminating dendritic function with computational models
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
From anatomy to function: the role of the somatosensory cortex in emotional regulation
Since the pioneering work of Penfield and his colleagues in the 1930s, the somatosensory
cortex, which is located on the postcentral gyrus, has been known for its central role in …
cortex, which is located on the postcentral gyrus, has been known for its central role in …
Mechanisms underlying gain modulation in the cortex
Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …
gain is modulated by internal and external influences, including attentional and arousal …