The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Abstract Major Depressive Disorder (MDD) is an affective disorder with sustained negative
affect and difficulties experiencing positive affect as its hallmark features. Previous work also …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Psilocybin is a classic psychedelic compound that may have efficacy for the treatment of
mood and substance use disorders. Acute psilocybin effects include reduced negative …

Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid
detection of threat. This pathway's existence is fundamental for understanding nonconscious …

Objectives The present study explored the effects of two prebiotics on the secretion of the
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …