Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

Protein–protein interactions (PPIs) regulate many cellular processes and engineered PPIs
have cell and gene therapy applications. Here, we introduce massively parallel PPI …

Breakthroughs in precision cell surface engineering tools are supporting the rapid
development of programmable living assemblies with valuable features for tackling complex …

Artificial RNA translation modulation usually relies on multiple components, such as RNA
binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

As words can have multiple meanings that depend on sentence context, genes can have
various functions that depend on the surrounding biological system. This pleiotropic nature …

Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate
harmful cells and modulate the immune system by dampening or stimulating inflammation …

So far, biocomputation strictly follows traditional design principles of digital electronics,
which could reach their limits when assembling gene circuits of higher complexity. Here, by …

Recent studies have shown that active colloidal motors using enzymatic reactions for
propulsion hold special promise for applications in fields ranging from biology to material …