Advancing diagnostic stewardship for healthcare-associated infections, antibiotic resistance, and sepsis

EJ Curren, JD Lutgring, S Kabbani… - Clinical Infectious …, 2022 - academic.oup.com
Diagnostic stewardship means ordering the right tests for the right patient at the right time to
inform optimal clinical care. Diagnostic stewardship is an integral part of antibiotic …

Beyond CGRP: The calcitonin peptide family as targets for migraine and pain

TA Rees, ER Hendrikse, DL Hay… - British journal of …, 2022 - Wiley Online Library
The CGRP system has emerged as a key pharmacological target for the treatment of
migraine. However, some individuals who suffer from migraine have low or no response to …

Society of Critical Care Medicine and the Infectious Diseases Society of America guidelines for evaluating new fever in adult patients in the ICU

NP O'Grady, E Alexander, W Alhazzani… - Critical care …, 2023 - journals.lww.com
OBJECTIVES: This is an update of the 2008 Infectious Diseases Society of America and
Society (IDSA) and Society of Critical Care Medicine (SCCM) guideline for the evaluation of …

The science of anastomotic healing

RB Morgan, BD Shogan - Seminars in Colon and Rectal Surgery, 2022 - Elsevier
Intestinal anastomotic tissue follows a similar pattern of healing that is seen in all tissues
with characteristic inflammatory, proliferative, and remodeling phases. Several aspects of …

The emerging role of presepsin (P-SEP) in the diagnosis of sepsis in the critically ill infant: a literature review

C Maddaloni, DU De Rose, A Santisi, L Martini… - International journal of …, 2021 - mdpi.com
Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence
varies between 5 and 170 per 1000 births, depending on the social context. In very low birth …

Acute pancreatitis: current clinical approaches, molecular pathophysiology, and potential therapeutics

MB Wiley, K Mehrotra, J Bauer, C Yazici… - Pancreas, 2023 - journals.lww.com
Objective Severe acute pancreatitis (SAP), pancreatic inflammation leading to multiorgan
failure, is associated with high morbidity and mortality. There is a critical need to identify …

[HTML][HTML] Elevated procalcitonin is positively associated with the severity of COVID-19: a meta-analysis based on 10 cohort studies

Y Shen, C Cheng, X Zheng, Y **, G Duan, M Chen… - Medicina, 2021 - mdpi.com
Background and Objectives: Procalcitonin (PCT) is positively associated with the severity of
COVID-19 (including severe, critical, or fatal outcomes), but some of the confounding factors …

28-day sepsis mortality prediction model from combined serial interleukin-6, lactate, and procalcitonin measurements: a retrospective cohort study

Y **e, D Zhuang, H Chen, S Zou, W Chen… - European Journal of …, 2023 - Springer
Sepsis is a global medical issue owing to its unacceptably high mortality rate. Therefore, an
effective approach to predicting patient outcomes is critically needed. We aimed to search …

Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19

S Wolfisberg, C Gregoriano… - Critical reviews in clinical …, 2022 - Taylor & Francis
Procalcitonin (PCT) is useful for differentiating between viral and bacterial infections and for
reducing the unnecessary use of antibiotics. As the rise of antimicrobial resistance reaches …

[HTML][HTML] A novel 29-messenger RNA host-response assay from whole blood accurately identifies bacterial and viral infections in patients presenting to the emergency …

W Bauer, K Kappert, N Galtung, D Lehmann… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: The rapid diagnosis of acute infections and sepsis remains a serious
challenge. As a result of limitations in current diagnostics, guidelines recommend early …