Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Neurodegenerative diseases such as Parkinson's disease (PD) are manifested by inclusion
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …

Aggregation of amyloidogenic proteins is a characteristic of multiple neurodegenerative
diseases. Atomic resolution of small molecule binding to such pathological protein …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Amyloid β (Aβ) ion channels destabilize cellular ionic homeostasis, which contributes to
neurotoxicity in Alzheimer's disease. The relative roles of various Aβ isoforms are poorly …

Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known
as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The …

While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …

The lemon essential oil (LEO), extracted from the fruit of lemon, has been used to treat
multiple pathological diseases, such as diabetes, inflammation, cardiovascular diseases …

Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with the
etiology of Parkinson's disease (PD), the most common motor neurodegenerative disorder …

Background MSA is a fatal neurodegenerative disease characterized by autonomic failure
and severe motor impairment. Its main pathological hallmark is the accumulation of α …