A review on biological activities of Schiff base, hydrazone, and oxime derivatives of curcumin

S Omidi, A Kakanejadifard - RSC advances, 2020 - pubs.rsc.org
Curcumin (1, 7-bis [4-hydroxy-3-methoxyphenyl]-1, 6-heptadiene-3, 5-dione) is the main
pigment present in the turmeric rhizome and shows various biological properties. The …

Developments in the anticancer activity of structurally modified curcumin: An up-to-date review

FC Rodrigues, NVA Kumar, G Thakur - European journal of medicinal …, 2019 - Elsevier
Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …

A review of recent curcumin analogues and their antioxidant, anti-inflammatory, and anticancer activities

K Kaur, AK Al-Khazaleh, DJ Bhuyan, F Li, CG Li - Antioxidants, 2024 - mdpi.com
Curcumin, as the main active component of turmeric (Curcuma longa), has been
demonstrated with various bioactivities. However, its potential therapeutic applications are …

Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets

E Chainoglou, D Hadjipavlou-Litina - Expert Opinion on Drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound,
which belongs to the curcuminoid family, presenting pleiotropic activity and low …

An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

L Arshad, MA Haque, SN Abbas Bukhari… - Future medicinal …, 2017 - Taylor & Francis
Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess
potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and …

Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats

MMT Eassawy, AA Salem… - Environmental …, 2021 - Wiley Online Library
Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in
some critical cases such as viral disease COVID‐19. However, the unrestricted use of APAP …

Reversible intramolecular proton transfer in curcumin crystals and nonlinear size correlation

X Wan, Y Chen, Y Cao, Z Gao, S Wu… - Crystal Growth & …, 2023 - ACS Publications
Intramolecular proton transfer is more difficult for curcumin in the solid state than in the
solution. In this study, a reversible transformation of keto-enol to the β-diketone form of …

[HTML][HTML] Novel amino acid derivatives bearing thieno [2, 3-d] pyrimidine moiety down regulate NF-κB in γ-irradiation mediated rat liver injury

NH Zaher, AAM Salem, AFM Ismail - Journal of Photochemistry and …, 2016 - Elsevier
A series of different amino acid-bearing thieno [2, 3-d] pyrimidine moiety was synthesized
via green chemistry aspects incorporating water as a solvent to give 2a–f, which were then …

[HTML][HTML] Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis

J Wu, K Ji, G Kang, M Zhang, J Wang, L Wang… - Pharmacological …, 2025 - Elsevier
Radiotherapy is a method of treating cancer through radiation aimed at killing cancer cells or
inhibiting their growth. However, radiotherapy has numerous side effects because it kills …

Modulatory effects of new curcumin analogues on gamma-irradiation–induced nephrotoxicity in rats

AFM Ismail, NH Zaher, EM El-Hossary… - Chemico-biological …, 2016 - Elsevier
In the present study, a new series of 2-amino-pyran-3-carbonitrile derivatives of curcumin 2–
7 have been synthesized via one-pot simple and efficient protocol, involving the reaction of …