Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

The use of cold preservation solutions to rapidly flush and cool the kidney followed by static
cold storage in ice has been the standard kidney preservation technique for the last 50 y …

The increased demand for organs has led to the increased usage of “higher risk” kidney and
liver grafts. These grafts from donation after circulatory death or expanded criteria donors …

Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor
kidney preservation and a promising novel strategy in higher risk donor livers in several …

Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of
debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or …

Ex vivo machine perfusion (EVMP) is an emerging technique for preserving explanted solid
organs with primary application in allogeneic organ transplantation. EVMP has been …

Background Supplemental oxygenation of the standard hypothermic machine perfusion
(HMP) circuit has the potential to invoke favorable changes in metabolism, optimizing …

HMP has proven to be beneficial as a kidney preservation method for all types of renal
grafts, most notably those retrieved from extended criteria donors. Large numbers of …

Organ transplantation remains the treatment of last resort in case of failure of a vital organ
(lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for …

The current data support the hypothesis that applying endischemic hypothermic machine
liver perfusion protects extended criteria DBD and DCD livers from initial reperfusion injury …