Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man
M Gerlach, P Riederer - Journal of neural transmission, 1996 - Springer
Animal models are an important aid in experimental medical science because they enable
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …
[PDF][PDF] Mitochondrial toxins and neurodegenerative diseases
Mitochondrial toxin involved in neurodegeneration 3. Toxin that produced a
neurodegeneration like that found in parkinson's disease 3.1. 1. Methyl-4-phenyl-1, 2, 3, 6 …
neurodegeneration like that found in parkinson's disease 3.1. 1. Methyl-4-phenyl-1, 2, 3, 6 …
Increased striatal dopamine turnover following acute administration of rotenone to mice
Because of the potential role of mitochondrial dysfunction in nigrostriatal degeneration in
Parkinson's disease, the effects of rotenone (an inhibitor of mitochondrial NADH …
Parkinson's disease, the effects of rotenone (an inhibitor of mitochondrial NADH …
The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro
EA Mazzio, RR Reams, KFA Soliman - Brain research, 2004 - Elsevier
The neurotoxin, 6-hydroxydopamine (6-OHDA) has been implicated in the
neurodegenerative process of Parkinson's disease. The current study was designed to …
neurodegenerative process of Parkinson's disease. The current study was designed to …
Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra …
J Han, FC Cheng, Z Yang… - Journal of …, 1999 - Wiley Online Library
In this investigation, microdialysis has been used to study the effects of 1‐methyl‐4‐
phenylpyridinium (MPP+), an inhibitor of mitochondrial complex I and α‐ketoglutarate …
phenylpyridinium (MPP+), an inhibitor of mitochondrial complex I and α‐ketoglutarate …
Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes
This review focuses on the biotransformation of cyclic tertiary amines and selected
azaarenes to potentially toxic metabolites. Special emphasis will be placed on 6-membered …
azaarenes to potentially toxic metabolites. Special emphasis will be placed on 6-membered …
1-Methyl-1, 2, 3, 4-tetrahydroisoquinoline, an endogenous amine with unexpected mechanism of action: new vistas of therapeutic application
L Antkiewicz-Michaluk, A Wąsik, J Michaluk - Neurotoxicity Research, 2014 - Springer
This review outlines the effects of 1, 2, 3, 4-tetrahydroisoquinoline (TIQ) and its derivative, 1-
methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ), endogenous substances imbued with …
methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ), endogenous substances imbued with …
Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse …
Environmental enrichment has been shown to be both neuroprotective and neurorestorative
in 1-methyl-2-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse models of Parkinson's …
in 1-methyl-2-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse models of Parkinson's …
Protective effect of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral …
L Antkiewicz-Michaluk, J Wardas… - International Journal …, 2004 - academic.oup.com
The aim of this paper was to investigate whether rotenone, a pesticide causing experimental
parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally …
parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally …
1-Methyl-1, 2, 3, 4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain
L Antkiewicz-Michaluk, B Karolewicz… - European journal of …, 2003 - Elsevier
The effect of single and multiple administration of the neurotoxic pesticide, rotenone, and the
potentially neuroprotective compound, 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ) …
potentially neuroprotective compound, 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ) …