Nanocarriers (NCs) that can precisely deliver active agents, nutrients and genetic materials
into plants will make crop agriculture more resilient to climate change and sustainable. As a …

Accurate determination of protein-ligand affinity is essential for drug design when new
compounds should be ranked according to their dissociation constants K d. The thermal shift …

Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

The binding affinity determination of protein–ligand complexes is a cornerstone of drug
design. State-of-the-art techniques are limited by lengthy and expensive processes. Building …

Highlights•An online tool for the protein–compound binding constant from thermal shift
data.•Provides estimates of the thermodynamic data on target proteins.•Thermott: free, user …

Natural product (NP)‐inspired design principles provide invaluable guidance for bioactive
compound discovery. Pseudo‐natural products (PNPs) are de novo combinations of NP …

All biological processes rely on the formation of protein–ligand, protein–peptide and protein–
protein complexes. Studying the affinity, kinetics and thermodynamics of binding between …

Clathrin forms a triskelion, or three-legged, network that regulates cellular processes by
facilitating cargo internalization and trafficking in eukaryotes. Its N-terminal domain is crucial …

Antimicrobial resistance genes, including multidrug efflux pumps, evolved long before the
ubiquitous use of antimicrobials in medicine and infection control. Multidrug efflux pumps …

G3BP is the central node within stress-induced protein–RNA interaction networks known as
stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually …