Objective Epilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …

Scaffolding proteins underlying postsynaptic membrane specializations are important
structural and functional components of both excitatory and inhibitory synapses. At inhibitory …

An inflammatory reaction in the brain is primarily characterized by activation of parenchymal
microglial cells. Microglia regulate several aspects of adult neurogenesis, ie the continuous …

New neurons are generated in the hippocampal dentate gyrus from early development
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …

Temporal lobe seizures lead to an acute inflammatory response in the brain primarily
characterized by activation of parenchymal microglial cells. Simultaneously, degeneration of …

Traumatic brain injury (TBI) increases hippocampal neurogenesis, which may contribute to
cognitive recovery after injury. However, it is unknown whether TBI-induced adult-born …

The hippocampus is a brain region well-known to exhibit structural and functional changes
in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those …

Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested
as potential factors underlying disorders like autism and schizophrenia resulting in …

Synapsins are pre-synaptic vesicle-associated proteins linked to the pathogenesis of
epilepsy through genetic association studies in humans. Deletion of synapsins causes an …

Electroconvulsive therapy (ECT) is a long-standing treatment choice for disorders such as
depression when pharmacological treatments have failed. However, a major drawback of …