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Map** complex disease traits with global gene expression
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases
JD Mills, M Janitz - Neurobiology of aging, 2012 - Elsevier
Alternative splicing (AS) is a post-transcriptional process that occurs in multiexon genes, and
errors in this process have been implicated in many human diseases. Until recently …
errors in this process have been implicated in many human diseases. Until recently …
Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in …
JR Highley, J Kirby, JA Jansweijer… - Neuropathology and …, 2014 - Wiley Online Library
Aims Loss of nuclear TDP‐43 characterizes sporadic and most familial forms of amyotrophic
lateral sclerosis (ALS). TDP‐43 (encoded by TARDBP) has multiple roles in RNA …
lateral sclerosis (ALS). TDP‐43 (encoded by TARDBP) has multiple roles in RNA …
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
Background—Much has been learned about transcriptional control of cardiac gene
expression in clinical and experimental congestive heart failure (CHF), but less is known …
expression in clinical and experimental congestive heart failure (CHF), but less is known …
A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data
Illumina BeadArrays are among the most popular and reliable platforms for gene expression
profiling. However, little external scrutiny has been given to the design, selection and …
profiling. However, little external scrutiny has been given to the design, selection and …
The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets–improving meta-analysis and prediction of prognosis
Background The number of gene expression studies in the public domain is rapidly
increasing, representing a highly valuable resource. However, dataset-specific bias …
increasing, representing a highly valuable resource. However, dataset-specific bias …
A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling
JR Bradford, Y Hey, T Yates, Y Li, SD Pepper, CJ Miller - BMC genomics, 2010 - Springer
Background RNA-Seq exploits the rapid generation of gigabases of sequence data by
Massively Parallel Nucleotide Sequencing, allowing for the map** and digital …
Massively Parallel Nucleotide Sequencing, allowing for the map** and digital …
Functional differences between mesenchymal stem cell populations are reflected by their transcriptome
Stem cells are widely studied to enable their use in tissue repair. However, differences in
function and differentiation potential exist between distinct stem cell populations. Whether …
function and differentiation potential exist between distinct stem cell populations. Whether …
Ocular manifestations of central insulin resistance
Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been
implicated in diabetes mellitus, Alzheimer's disease and other neurological disorders …
implicated in diabetes mellitus, Alzheimer's disease and other neurological disorders …
A comparison of Affymetrix gene expression arrays
Abstract Background Affymetrix GeneChips™ are an important tool in many facets of
biological research. Recently, notable design changes to the chips have been made. In this …
biological research. Recently, notable design changes to the chips have been made. In this …