DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and
high target recognition specificity for disease diagnosis. This review provides a critical …

Engineering functional nucleic acids that are active under unusual conditions will not only
reveal their hidden abilities but also lay the groundwork for pursuing them for unique …

Functional nucleic acids (FNAs), including naturally occurring ribozymes and riboswitches
as well as artificially created DNAzymes and aptamers, have been popular molecular …

We found U2R1, a previously discovered G-rich DNA sequence, could form the G-
quadruplex (G4) structure at high temperature and maintain high stability. By utilizing its …

The staining of nucleic acids with fluorescent dyes is one of the most fundamental
technologies in relevant areas of science. For reliable and quantitative analysis, the staining …

Theta-mediated end-joining (TMEJ) is critical for survival of cancer cells when other DNA
double-stranded break repair pathways are impaired. Human DNA polymerase theta (Pol θ) …

The solute urea has been used extensively as a denaturant in protein folding studies;
double-stranded nucleic acid structures are also destabilized by urea, but comparatively …

Biosensors play an important role in numerous research fields. Quartz crystal microbalances
with dissipation monitoring (QCM-Ds) are sensitive devices, and binding events can be …

In recent years, therapeutic siRNA projects are booming in the biotech and pharmaceutical
industries. As these drugs act by silencing the target gene expression, a critical step is the …

Metal recognition by nucleic acids provides an intriguing route for biosensing of metal.
Toward this goal, a key prerequisite is the acquisition of nucleic acids that can selectively …