Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is
characterized by chronic relapsing intestinal inflammation. It has been a worldwide health …

After drifting apart for 100 years, the two worlds of genetics—quantitative genetics and
molecular genetics—are finally coming together in genome-wide association (GWA) …

Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major
histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing …

Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively
regulates all cell types involved in the initiation, propagation, and resolution of inflammation …

Objective To explore the composition of the intestinal microbiota in ulcerative colitis (UC)
patients and to identify differences in the microbiota between patients with active disease …

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a
previously unknown susceptibility locus at ECM1. We also show that several risk loci are …

Abstract The IL-23/Th17 pathway has recently been identified to play a critical role in a
number of chronic inflammatory diseases including inflammatory bowel disease (IBD). The …

From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …

Protracted inflammation leading to dysregulation of effector T‐cell responses represents a
common feature of a wide range of autoimmune diseases. The interleukin‐12 (IL‐12)/T …