Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
The pathogenesis and treatment of theCytokine Storm'in COVID-19
Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
Cytokine storm is a general term applied to maladaptive cytokine release in response to
infection and other stimuli. The pathogenesis is complex but includes loss of regulatory …
infection and other stimuli. The pathogenesis is complex but includes loss of regulatory …
Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report
Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI) …
injury have created the need to update the definition of experimental acute lung injury (ALI) …
Diversity of macrophages in lung homeostasis and diseases
F Hou, K **ao, L Tang, L **e - Frontiers in immunology, 2021 - frontiersin.org
Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …
clearance and immune regulation. The different types of pulmonary macrophages and their …
Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic
coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild …
coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild …
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12
Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we
show that mice develop inflamed lung tissue after being administered exosomes released …
show that mice develop inflamed lung tissue after being administered exosomes released …
[HTML][HTML] The mechanism behind influenza virus cytokine storm
Y Gu, X Zuo, S Zhang, Z Ouyang, S Jiang, F Wang… - Viruses, 2021 - mdpi.com
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-
cell communication and viral clearance in the immune system, but excessive cytokines can …
cell communication and viral clearance in the immune system, but excessive cytokines can …
Macrophages: Their role, activation and polarization in pulmonary diseases
Macrophages, circulating in the blood or concatenated into different organs and tissues
constitute the first barrier against any disease. They are foremost controllers of both innate …
constitute the first barrier against any disease. They are foremost controllers of both innate …
[HTML][HTML] Type I interferons in infectious disease
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …