Mechanisms of viral inflammation and disease in humans
Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …
infection, and the replication level correlates with the likelihood of viral transmission. Here …
Human autoantibodies underlying infectious diseases
The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …
silent infection to lethal disease—is increasingly being explained by human genetic and …
Human life within a narrow range: The lethal ups and downs of type I interferons
YJ Crow, JL Casanova - Science immunology, 2024 - science.org
The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
Epidemiology and immune pathogenesis of viral sepsis
GL Lin, JP McGinley, SB Drysdale… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
Shared genetic risk factors and causal association between psoriasis and coronary artery disease
Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …
established, but whether a genetic basis underlies this is not well studied. We apply trans …
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease
As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a
growing need to assess its impact in patients with autoimmune rheumatic diseases, such as …
growing need to assess its impact in patients with autoimmune rheumatic diseases, such as …
[HTML][HTML] A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from
silent infection to lethal disease. The role of human genetics in determining clinical response …
silent infection to lethal disease. The role of human genetics in determining clinical response …