DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

The classification working group of the International Society of Urological Pathology
consensus conference on renal neoplasia was in charge of making recommendations …

Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

Lung cancer remains the leading cause of cancer‐related death due to poor treatment
responses and resistance arising from tumour heterogeneity. Here, we show that adverse …

The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …

Ras proteins function as signal transducers and are mutationally activated in many human
cancers. In 1993, Raf was identified as a key downstream effector of Ras signaling, and it …

The detection of promoter region hypermethylation and transcriptional silencing has
facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor …