Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …

Flotillins are membrane proteins that form microdomains in the plasma membrane of all
mammalian cell types studied to date. They span the evolutionary spectrum, with proteins …

Reggie/flotillin proteins are considered to be components of lipid rafts and are commonly
used as marker proteins for lipid microdomains. Yet almost a decade after their discovery …

Plasma levels of high-density lipoproteins (HDL) and apolipoprotein AI (apoA-I) are
inversely correlated with the risk of cardiovascular disease. One major atheroprotective …

Atherosclerosis, driven by inflamed lipid-laden lesions, can occlude the coronary arteries
and lead to myocardial infarction. This chronic disease is a major and expensive health …

The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 and-A7) show
sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the clearance …

The ATP-binding cassette transporters, ABCA1 and ABCG1, are major players in mediating
cellular efflux of phospholipids and cholesterol to apoA-I containing lipoproteins including …