Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

The classification of histamine receptors has to date been based on rigorous classical
pharmacological analysis, and as yet, the classification of the three histamine receptors that …

Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important
roles in various physiological and pathophysiological conditions. Antihistamines that target …

The recognition of histamine (HA)[or 2 (4-imidazolyl) ethylamine] as a messenger molecule
in cell-to-cell communication began early in this century. The early history of HA was …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile
group of cell surface receptors. Drugs active at these receptors have therapeutic actions …

The localization of histamine H 1-receptors in the rat brain was studied at the light
microscopic level by quantitative autoradiography. Receptors were labeled in vitro with [3 H] …

Histamine, a biological amine, is considered as a principle mediator of many pathological
processes regulating several essential events in allergies and autoimmune diseases. It …

Abstract [125 I] Iodobolpyramine, a potent and selective histamine H 1-receptor antagonist
derived from mepyramine, was used to generate light microscopic autoradiograms on …

Abstract [3H] Mepyramine binds with high affinity to membranes from brain of human, rat,
guinea‐pig, rabbit and mouse with drug specificity indicating an association with histamine …