The coronavirus nucleocapsid is a multifunctional protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic
RNA, interacts with the viral membrane protein during virion assembly and plays a critical …
RNA, interacts with the viral membrane protein during virion assembly and plays a critical …
Intrinsically disordered protein
Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the
random coil. The five following examples suggest that native protein structure can …
random coil. The five following examples suggest that native protein structure can …
Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward… - Nature chemical …, 2022 - nature.com
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …
Intrinsically disordered proteins and intrinsically disordered protein regions
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
Understanding protein non-folding
This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
Protein disorder prediction: implications for structural proteomics
A great challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …
structure and function, including identification of those proteins that are partially or wholly …
Intrinsic disorder in cell-signaling and cancer-associated proteins
The number of intrinsically disordered proteins known to be involved in cell-signaling and
regulation is growing rapidly. To test for a generalized involvement of intrinsic disorder in …
regulation is growing rapidly. To test for a generalized involvement of intrinsic disorder in …
Flexible nets: the roles of intrinsic disorder in protein interaction networks
Proteins participate in complex sets of interactions that represent the mechanistic foundation
for much of the physiology and function of the cell. These protein–protein interactions are …
for much of the physiology and function of the cell. These protein–protein interactions are …
GlobPlot: Exploring protein sequences for globularity and disorder
A major challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …
structure and function, including identification of those proteins that are partially or wholly …
Rapid prediction and analysis of protein intrinsic disorder
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …