Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

The gasdermin (GSDM) family has garnered significant attention for its pivotal role in
immunity and disease as a key player in pyroptosis. This recently characterized class of pore …

The immune system plays a critical role in sha** all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Regulated cell death (RCD) triggered by innate immune activation is an important strategy
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …

Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes.
Accumulation of these chemicals has adverse effects on human health, including …

Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

Background Uncontrollable inflammation is a critical feature of gram-negative bacterial
pneumonia-induced acute respiratory distress syndrome (ARDS). Both neutrophils and …