Hematopoietic stem and progenitor cells maintain blood formation throughout our lifetime by
undergoing long-and short-term self-renewal, respectively. As progenitor cells progress …

Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with
CD4+ Th2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored …

Many human diseases arise through dysregulation of genes that control key cell fate
pathways. Transcription factors (TFs) are major cell fate regulators frequently involved in …

Growth factor independence 1 (GFI1) is a DNA binding zinc finger protein, which can
mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its …

There is much current interest in the role of the platelet storage pool of α‐granule proteins
both in hemostasis and non‐hemostatic events. As well as in the arrest of bleeding, the …

RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and
thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters …

Differentiation of hematopoietic stem cells is regulated by a concert of different transcription
factors. Disturbed transcription factor function can be the basis of (pre) malignancies such as …

Understanding the production and differentiation of megakaryocytes from progenitors is
crucial for realizing the biology and functions of these vital cells. Previous gene ablation …

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in
signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS …

During human development, the globin subunits of haemoglobin undergo two switches: first
from embryonic to fetal subunits, and then from fetal to adult subunits. Reactivating fetal …