The development of complex and diverse metazoan morphologies is coordinated by a
surprisingly small number of evolutionarily conserved signaling mechanisms. These signals …

The Ras and Notch signaling pathways are used over and over again during development
to control many different biological processes. Frequently, these two signaling pathways …

The microRNA miR-7 is perfectly conserved from annelids to humans, and yet some of the
genes that it regulates in Drosophila are not regulated in mammals. We have explored the …

A critical question about signal transduction is how weak or transient activation of signaling
pathways achieves a robust and long-term switch in gene expression. We report that a …

In multicellular organisms, apoptotic cells induce compensatory proliferation of neighboring
cells to maintain tissue homeostasis. In the Drosophila wing imaginal disc, dying cells trigger …

The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue
growth and metabolism in multicellular animals. Although core components of the pathway …

Background Cis-regulatory modules are combinations of regulatory elements occurring in
close proximity to each other that control the spatial and temporal expression of genes. The …

The Drosophila eye is a highly ordered epithelial tissue composed of∼ 750 subunits called
ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of …

Metazoan development relies on a highly regulated network of interactions between
conserved signal transduction pathways to coordinate all aspects of cell fate specification …

Immature double positive (DP) thymocytes bearing a T cell receptor (TCR) that interacts with
self‐major histocompatibility complex (MHC) molecules receive signals that induce either …