Physical traits of cancer
BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …
mutations in genes that control proliferation, differentiation, and death. In recent decades …
Mechanotransduction and extracellular matrix homeostasis
JD Humphrey, ER Dufresne… - Nature reviews Molecular …, 2014 - nature.com
Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …
environmental cues and respond to them to promote homeostasis, including maintenance of …
Tissue cells feel and respond to the stiffness of their substrate
Normal tissue cells are generally not viable when suspended in a fluid and are therefore
said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as …
said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as …
[HTML][HTML] Tensional homeostasis and the malignant phenotype
MJ Paszek, N Zahir, KR Johnson, JN Lakins… - Cancer cell, 2005 - cell.com
Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins
are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could …
are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could …
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
The morphology and cytoskeletal structure of fibroblasts, endothelial cells, and neutrophils
are documented for cells cultured on surfaces with stiffness ranging from 2 to 55,000 Pa that …
are documented for cells cultured on surfaces with stiffness ranging from 2 to 55,000 Pa that …
Control of stem cell fate by physical interactions with the extracellular matrix
A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …
Stiffness sensing by cells
PA Janmey, DA Fletcher… - Physiological …, 2020 - journals.physiology.org
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …
signals are important elements in normal tissue development as well as in disease initiation …
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
Contractile myocytes provide a test of the hypothesis that cells sense their mechanical as
well as molecular microenvironment, altering expression, organization, and/or morphology …
well as molecular microenvironment, altering expression, organization, and/or morphology …
Biomechanics and biophysics of cancer cells
S Suresh - Acta biomaterialia, 2007 - Elsevier
The past decade has seen substantial growth in research into how changes in the
biomechanical and biophysical properties of cells and subcellular structures influence, and …
biomechanical and biophysical properties of cells and subcellular structures influence, and …