Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm with high morbidity
and mortality. The initiating mechanism during the pathogenesis of KHE has yet to be …

Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

A platelet activation receptor, C‐type lectin‐like receptor 2 (CLEC‐2), has been identified as
a receptor for a platelet‐activating snake venom, rhodocytin. CLEC‐2 protein is highly …

Mice with a constitutive or platelet-specific deletion of the C-type-lectin-like receptor (CLEC-
2) exhibit hemorrhaging in the brain at mid-gestation. We sought to investigate the basis of …

Podoplanin/Aggrus is a sialoglycoprotein expressed in various cancers. We previously
identified podoplanin as a key factor in tumor-induced platelet aggregation. Podoplanin …

Podoplanin (PDPN) is a transmembrane glycoprotein that plays crucial roles in embryonic
development, the immune response, and malignant progression. Here, we report that cells …

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous
thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on …